Organic nitroso compounds
Medchemexpress LLC (R)-PR-924 | 98.5% | 618.72 | 1 ML
(R)-PR-924 is an isomer of PR-924, which is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It can be used as an experimental control. PR-924 covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, also exhibiting antitumor activities.
- Used as an experimental control
- Selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor
- Covalently modifies proteasomal N-terminal threonine active sites
- Inhibits growth and triggers apoptosis in multiple myeloma (MM) cells
- Exhibits antitumor activities
Cayman Chemical 5-NItroso-8-quInolInol 50mg
An HDAC inhibitor, antitumor agent that at 10 μM can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells; inhibits T. gondii tachyzoite propagation in human fibroblasts (EC50 = 80 nM) and inhibits P. falciparum growth in human red blood cells (EC50 = 1.3 μM)
Medchemexpress LLC N-nitrosomorpholine-d8 | 1219805-76-1 | 99.7% | C4D8N2O2 | 10MG
N-Nitrosomorpholine-d8 is the deuterium-labeled analog of N-nitrosomorpholine, provided as an isotope-labeled internal standard for analytical and tracer applications. It is intended for quantitative analysis and method development in NMR, GC-MS, and LC-MS assays. The compound is light-sensitive and is a known strong animal carcinogen; handle with appropriate safety precautions.
- Deuterium labeled for use as an internal standard in quantitative NMR, GC-MS, and LC-MS.
- High chemical purity (99.74%).
- Molecular formula C4D8N2O2 and molecular weight 124.17.
- Available in small, analytical sizes suitable for reference standards.
- Light-sensitive; requires controlled storage and handling.
- Suitable as a tracer for method development and quantitative analysis.
Sigma Aldrich Fine Chemicals Biosciences N-Nitrosodiethylamine ISOPAC(R) | 55-18-5 | MFCD00013890 | 1G
N-Nitrosodiethylamine ISOPAC(R) | Mol Wt: 102.14 | 55-18-5 | MFCD00013890 | 1G
Sigma Aldrich Fine Chemicals Biosciences N-Nitrosodiethylamine Phar1G
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC N-Nitrosomorpholine | 59-89-2 | 99.9% | 1 G
N-Nitrosomorpholine is a photosensitive nitrosamine known for its carcinogenic properties, primarily used in research to construct animal cancer models. It is intended for research applications only and not for patient use.
- Carcinogenic agent for research purposes.
- Used to construct animal cancer models.
- Induces liver disease, including cytoplasmic and nuclear changes.
- Causes toxic damage, single-cell necrosis, and loss of glycogen.
- Promotes giant cell production, bile duct proliferation, and fibrosis.
- Leads to cirrhosis and metastatic liver cancer in animal models.
- Supports the study of molecular and histological changes, including increased serum glutamate-oxaloacetate aminotransferase levels and liver damage.
Medchemexpress LLC Tripeptide epoxyketone immunoproteasome (LMP-7) inhibitor | 1416709-79-9 | 98.9% | 618.72 g/mol | C37H38N4O5 | 50MG
A selective tripeptide epoxyketone inhibitor of the immunoproteasome LMP7 subunit for biochemical and cellular research. It covalently modifies proteasomal N-terminal threonine active sites and has demonstrated antitumor activity in preclinical studies.
- Selective LMP7 (β5i) immunoproteasome inhibitor.
- Covalently modifies N-terminal threonine active sites.
- Reported IC50 of 22 nM against LMP7.
- Demonstrated inhibition of multiple myeloma cell growth and induction of apoptosis.
- High chemical purity (98.9%).
- Enantiomeric excess 100%.
- Molecular weight 618.72 g/mol and formula C37H38N4O5.
- Supplied in small research pack sizes, e.g., 50 mg.
- For research use only; not for human use.
Cayman Chemical 5-NItroso-8-quInolInol 10mg
An HDAC inhibitor, antitumor agent that at 10 μM can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells; inhibits T. gondii tachyzoite propagation in human fibroblasts (EC50 = 80 nM) and inhibits P. falciparum growth in human red blood cells (EC50 = 1.3 μM)
AdipoGen DETA NONOate,Chemical. CAS: 146724-94-9
DETA NONOate, AdipoGen Life Sciences. Chemical. CAS: 146724-94-9. Formula: C4H13N5O2. MW: 163.2. Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37?C and 56 hours at 22-25?C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
World Precision Instrument SNAP S-Nitroso-N-acetyl-D-penicillamine-SNAP50
SNAP is a stable green crystalline S-nitrosothiol compound that mimics the action of nitric oxide in vivo. It has vasodilatory properties and has been shown to relax isolated bovine coronary artery rings by activating soluble granulate cyclase. This reagent also actuates apoptosis in mouse thymocytes and has been accounted for reversible inactivation of protein Kinase C. SNAP can be used for calibration of all WPI NO sensors. Call for details. M.W. 220.2, Purity > 98% by NMR or TLC.
Enzo Life Sciences Spermine NONOate (25mg). CAS: 136587-13-8
Nitric oxide (NO) donor. A convenient reagent for preparing aqueous solutions of NO. Alternative name: SPER/NO, (Z)-1-N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino-diazen-1-ium-1,2-diolate. Purity: ≥97% (NMR). Appearance: White to off-white crystalline solid. Solubility: Soluble in water, methanol or 100% ethanol. Long Term Storage: -80°C.
Enzo Life Sciences Spermine NONOate (5mg). CAS: 136587-13-8
Nitric oxide (NO) donor. A convenient reagent for preparing aqueous solutions of NO. Alternative name: SPER/NO, (Z)-1-N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino-diazen-1-ium-1,2-diolate. Purity: ≥97% (NMR). Solubility: Soluble in water, methanol or 100% ethanol. Long Term Storage: -80°C.